Degeneration of the cholinergic system in subjective cognitive decline: A systematic review

Background Subjective cognitive decline (SCD) is topic of mayor interest when identifying individuals at risk for future impairment and dementia. The degeneration the cholinergic system linked to onset symptoms in mild (MCI) Yet, it uncertain whether neurodegeneration already present SCD individuals. This review first synthetize available data on association with multiple markers system. Method Following PRISMA guidelines, original articles focused were extracted from three databases: Pubmed, WOS Scopus, November 2021. Two researchers reviewed studies independently a 2-stepwise approach. quality bias assessed using FLC 3.0, that allows systematically evaluate summarize them easily. Result Among 119 found our systematic search, 11 included current review. Seven cross-sectional 4 had longitudinal design. Most operationalized based amnestic complaints (n = 9, 82%). measures neuroimaging volume basal forebrain and/or functional connectivity, transcranial magnetic stimulation, or biofluid (i.e. cerebrospinal fluid (CSF) plasma). brain atrophy, 75% reported reduce volumes SCD; From those connectivity system, 33% poorer SCD. Conclusion Based scientific evidence, evident during Using biomarkers, seems occur significant structural nuclei their connections other areas. These findings have implications increased vulnerability targeting might benefit cholinergic-target treatments. Further research needed elucidate potential contributors its impact cognition clinical progression.